The $160MM Synergy: Leading Across Disciplines
Most surgeons stay in the hospital. I went back to the engineering lab.
We have a structural flaw in how we approach progress. We’ve built a world of high-walled silos. Surgeons stay in the OR. Engineers stay in the lab. Private equity stays in the spreadsheet.
Each group speaks its own dialect, follows its own KPIs, and ignores the others. We’ve specialized ourselves into a corner where innovation has slowed to a crawl because no one is looking over the fence.
But as a surgeon with an engineering degree from Rose-Hulman, I realized early on that the most valuable real estate in the world isn’t in a hospital or a boardroom. It’s the intersection. If you want to create exponential value, you have to leave the hospital and go back to the lab. You have to become a translator between worlds.
The Silo Trap
In medicine, we are taught to be “Subject Matter Experts.” We go deep, not wide. But deep expertise without broad context is a recipe for stagnation.
I’ve seen brilliant surgeons complain about implant failures for a decade without ever talking to the person who designed the alloy. I’ve seen engineers build “perfect” tools that are impossible to use in a bloody, high-pressure surgical field.
This is the Silo Trap: The belief that your discipline has all the answers.
When I look at a hip replacement, I don’t just see a medical procedure. I see a tribological challenge (friction and wear), a fiscal event (the economics of the ASC), and a biological war (inflammation). To lead a breakthrough, I can’t just be the “doctor.” I have to be the Systems Architect.
The $160 Million Bridge
I’m currently seeing this “Interdisciplinary Synergy” play out in a massive way.
Through a $30MM Lilly Foundation Grant and a $160MM NSF grant application, we are bridging the gap between Rose-Hulman Institute of Technology, Union Health, and the Indiana Orthopedic Institute.
Most people see these as separate entities: a school, a hospital, and a private practice. I see them as a single, high-performance engine.
By bringing engineering students into the clinical environment and putting surgeons into the biomechanical lab, we are shortening the innovation cycle from years to months. We aren’t just “collaborating” - we are vertically integrating the intellect. This is how you move from incremental improvements to market-disrupting breakthroughs.
The Interdisciplinary Protocol
You don’t need a $160MM grant to lead across disciplines. You just need to change your leadership “OS.” Here is how I manage the synergy between medicine, engineering, and private equity:
1. Learn the Dialects To lead a cross-functional team, you must be a polyglot. You need to understand a P&L statement as well as you understand an X-ray. You need to speak “Torque” to the engineer and “EBITDA” to the investor. When you can translate the needs of one group into the language of another, friction disappears.
2. Hunt the Intersection The biggest problems in any industry usually sit in the “no-man’s land” between departments. Search for the friction points where the OR meets the supply chain, or where the technology meets the patient experience. That is where the $100M ideas are hiding.
3. Build a “Multi-Chassis” Team At IOI, I don’t just hire for clinical skill. I look for people who have “hybrid” backgrounds - nurses who understand tech, or administrators who understand the mechanical reality of surgery. A team with diverse “mental models” will always out-innovate a team of identical specialists.
4. The Engineering Audit Every clinical problem is an engineering problem in disguise. When we face a challenge in patient outcomes, we don’t just ask “What is the medicine?” We ask “What is the mechanical failure?” Apply an engineering audit to your business operations. Look for the stress points, the bottlenecks, and the drag.
The Bottom Line
Specialization is for machines. Synergy is for leaders.
The “Human Machine” is too complex to be solved by one discipline. If you stay in your silo, you are choosing a linear career path in an exponential world.
Break out of the hospital. Go back to the lab. Find the intersection and stay there until you find the breakthrough.
Are you protecting your silo, or are you building a bridge?
Michael Meneghini, MD
If you found this helpful, share it with a leader who is stuck in a silo. Next week, we are diving into “The Surgeon-Owner”… why vertical integration is the only cure for a broken system.




Translating between disciplines isn’t a nice to have, it’s how breakthrough value is actually created, and your Systems Architect framing captures that perfectly
I recognise this in some of the team worked in and led.
Rarely is failure dramatic, it’s usually the slow cost of things not quite lining up, people, expectations, or decisions.
And, lands clearly across the voices:
Nurturers might feel strain when relational load isn’t shared.
Guardians might notice where tolerances are exceeded.
Creatives might sense when ideas aren’t integrated.
Connectors might feel the friction between parts that should meet.
Pioneers might push forward, sometimes before alignment has settled.
Naming these dynamics helps leaders adjust before damage appears.