8 Comments
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John Brewton's avatar

Just because something works does not mean we understand the full cost.

Swanlzs's avatar

Great article. My BIL was on them for T2D and weight loss. He also had bone loss and lost several teeth. Was told it was a side effect :-(. He's not in great health overall anyway.

Patti Wohlin's avatar

Thank you for your honest review, Dr. Meneghini. Your point: "If a patient is on a GLP-1 and not lifting, they are losing muscle. Full stop." This hidden factor bothers me most. I'm not overly concerned about the use of the drug, it's my concern that people aren't informed or motivated enough to do what it takes to be better off due to its use. The hype might be blurring the real fact that lifestyle matters, especially if the drug is started.

Daniel Ionescu's avatar

Yep, GLP-1s do quiet the food noise.

They cannot build the rest for you.

If muscle drops, the habits never form, and the weight comes back once you stop taking them...

...the story was never as simple as people wanted it to be.

I wrote about my experience too. 🔗 https://millennialmasters.net/p/glp1-discipline

Juan Salas-Romer's avatar

Thank you for your thoughtful piece. Your call to slow down, protect muscle and bone, and avoid rushing into lifelong high-dose use is a much-needed, balanced surgeon’s perspective.

Passport Inspiration's avatar

wild how popular these drugs are now, feel like most people don’t actually understand what they do

Daniel Lee's avatar

Excellent and thoughtful perspective.

Sean Mize's avatar

Thanks for sharing the details especially about the muscle loss - it's scary because while fat is so much easier to put back on after losing it, the muscle won't come back easily - and could cripple folks down the road - Thanks again for sharing